The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
7
Vitamin D3 aids heart health
Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts.
We explored the effects of vitamin D3 (VitD) on heart cells, focusing on its ability to counteract changes induced by angiotensin II (Ang II), a compound that can contribute to heart disease. The study involved exposing H9c2 cardiomyoblasts—heart muscle cells—to Ang II alone, and then to both Ang II and VitD to see how VitD might help.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Read More
3
Vitamin D3's limited heart health effects
Vitamin D and cardiovascular outcomes in multiple sclerosis.
We explored the connection between vitamin D levels and cardiovascular health in people with multiple sclerosis (pwMS). Specifically, our study examined the effects of vitamin D3 treatment on heart-related outcomes among patients with differing levels of vitamin D. Using data from 70 healthcare organizations over a period of five years, we focused on individuals who had either deficient or adequate vitamin D levels.
Our findings revealed that pwMS with deficient or inadequate vitamin D levels experienced an increased risk of major adverse cardiovascular events (MACE), including heart attacks and strokes. Importantly, while some pwMS received cholecalciferol (a form of vitamin D3) supplementation, this did not significantly reduce their risk of heart problems compared to those with adequate vitamin D levels who were not taking supplements.
Overall, our inquiry shows that simply having adequate vitamin D is crucial, but supplementation with vitamin D3 alone may not confer the expected cardiovascular protective benefits for pwMS. This suggests that more comprehensive strategies may be needed to address heart health in these patients.
Read More
Most Useful Reviews
9
Effective vitamin combo
9 people found this helpful
Checked, it works. The combination of vitamins D and K is excellent. I feel superb after taking it with omega and vitamin C. During a recent illness, I found taking a loading dose along with vitamin C and zinc crucial; I experienced minimal symptoms. This product is just what I needed, and I appreciate its efficacy, so I encourage others to try it for their cardiovascular health.
Read More
9
Comprehensive support
7 people found this helpful
The D3-K and iodine combination is remarkable! Vitamin D is essential for the body's functioning beyond just bone health; it also impacts cardiovascular functions. Since my doctor advised that vitamin K is vital for effective calcium metabolism, this formula offers everything in one capsule. I'm pleased with the results, especially in improving cardiovascular health.
Read More
9
Universal health benefits
3 people found this helpful
This supplement is essential for everyone, given my experience as a trainer and nutritionist. My entire family has benefited, as well as my clients, with notable improvements in well-being and cardiovascular health. However, I advise against its use for those with thyroid or heart conditions.
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
7
Vitamin D3's influence on CVD risk
Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study.
We explored how different vitamin D treatments may influence cardiovascular disease (CVD) risk among patients with chronic kidney disease (CKD). Our observational study included 83 CKD patients who were treated with vitamin D or its analogs and had varying histories of CVD. By measuring the thickness of perirenal adipose tissue (PAT) and assessing clinical parameters, we aimed to uncover any links between vitamin D treatment and cardiovascular health.
We found that patients with a history of CVD showed thicker PAT compared to those without such a history. Interestingly, our comparisons among patients receiving different forms of vitamin D revealed that those treated with paricalcitol had less PAT accumulation than those on cholecalciferol or calcitriol. This suggests that the type of vitamin D treatment may play a role in managing CVD risk in CKD patients.
Although our findings indicate differences in PAT thickness related to vitamin D treatment, we did not conduct a controlled trial that would allow us to claim a definitive benefit of vitamin D3 alone on cardiovascular health. It appears that further investigation is necessary to clarify these relationships and understand the mechanisms at play.
Read More
7
Vitamin D3 aids heart health
Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts.
We explored the effects of vitamin D3 (VitD) on heart cells, focusing on its ability to counteract changes induced by angiotensin II (Ang II), a compound that can contribute to heart disease. The study involved exposing H9c2 cardiomyoblasts—heart muscle cells—to Ang II alone, and then to both Ang II and VitD to see how VitD might help.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
Read More
7
Vascular calcification insights explored
Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling.
In exploring how vitamin D3 influences cardiovascular disease, we conducted experiments with both young and aged mice, who were treated with vitamin D3 or saline to assess its impact on vascular calcification. Out of our findings, it was crucial to note that while vitamin D3 treatments were utilized, we also incorporated Elabela and other compounds, making it challenging to isolate vitamin D3's specific effects on cardiovascular health fully.
Through our study, we observed the potential protective role of Elabela against vascular calcification, particularly acting through pathways that involve PPAR-γ and FDX1 signaling. However, the combination of treatments lacks clarity on the specific benefits of vitamin D3 by itself in managing vascular health. Thus, the data does not present a clear advantage for vitamin D3 in reducing cardiovascular disease risks when considered independently from Elabela.
Overall, our research underlines the complexity of vitamin D3's role in cardiovascular conditions and indicates that more targeted studies are necessary to define its specific contributions clearly.
Read More
7
Vitamin D3's cardiovascular association analyzed
[Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES].
We explored how serum levels of vitamin D3, specifically 25(OH)D, might influence various indicators related to cardiovascular health. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2015 to 2018, we analyzed results from 4,727 adults aged 20 and above.
Our investigation focused on several key factors such as body mass index, high-density lipoprotein cholesterol, systolic blood pressure, and cholesterol levels. The results showed that even a slight increase in vitamin D3 levels was associated with positive changes across these cardiovascular risk factors. For instance, we found that a 1 nmol/L increase in serum 25(OH)D led to small but significant improvements in several indicators.
Notably, the effects varied by gender and age, with women showing greater sensitivity to vitamin D3 levels compared to men, while older adults were less responsive. However, our findings highlighted a complex relationship, revealing nonlinear patterns that suggest additional research is necessary to fully understand these dynamics. While the results display promising associations, they do not confirm that vitamin D3 treatment can directly improve cardiovascular disease outcomes.
Checked, it works. The combination of vitamins D and K is excellent. I feel superb after taking it with omega and vitamin C. During a recent illness, I found taking a loading dose along with vitamin C and zinc crucial; I experienced minimal symptoms. This product is just what I needed, and I appreciate its efficacy, so I encourage others to try it for their cardiovascular health.
Read More
9
Comprehensive support
7 people found this helpful
The D3-K and iodine combination is remarkable! Vitamin D is essential for the body's functioning beyond just bone health; it also impacts cardiovascular functions. Since my doctor advised that vitamin K is vital for effective calcium metabolism, this formula offers everything in one capsule. I'm pleased with the results, especially in improving cardiovascular health.
Read More
9
Universal health benefits
3 people found this helpful
This supplement is essential for everyone, given my experience as a trainer and nutritionist. My entire family has benefited, as well as my clients, with notable improvements in well-being and cardiovascular health. However, I advise against its use for those with thyroid or heart conditions.
Read More
9
Effective composition
I started this supplement due to calcium affecting my cardiovascular system. It effectively directs calcium to my bones and protects my blood vessels. I highly recommend it, especially in areas with limited sunlight.
Read More
9
Cognitive health support
This formula provides essential nutrients: 125 mcg Vitamin D3, 2100 mcg Vitamin K, and 1000 mcg iodine, supporting cardiovascular disease and cognitive health. Maintaining healthy vitamin levels is vital for bone density and overall well-being.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Vitamin D3 K2 is a supplement that combines two vital nutrients: vitamin D3 (cholecalciferol) and vitamin K2 (menaquinone). Vitamin D3 is crucial for maintaining healthy bones and immune function, as it helps the body absorb calcium, which is essential for bone strength. It can be obtained through sunlight exposure, certain foods, and supplements. On the other hand, vitamin K2 plays a significant role in directing calcium to the bones and teeth while preventing it from depositing in the arteries and soft tissues, thus promoting cardiovascular health and overall well-being.
The synergy between vitamin D3 and K2 is particularly important because they work together to ensure that calcium is utilized effectively in the body. While vitamin D3 boosts calcium absorption, vitamin K2 ensures that this calcium is deposited properly in the bones rather than accumulating in the arteries. This combination is believed to support bone density, cardiovascular health, and overall vitality. Many health professionals recommend considering a D3 and K2 supplement, especially for individuals who may be at risk of deficiency or those who live in areas with limited sunlight exposure. Always consult a healthcare provider before starting any new supplement regimen.
The potential benefits of Vitamin D3 and K2 for cardiovascular health have been the subject of various studies, but the evidence remains inconclusive. Vitamin D3 is known for its role in calcium metabolism and may influence heart health by regulating blood pressure and inflammation. Some studies suggest that adequate levels of Vitamin D3 can lead to improved cardiovascular outcomes, particularly in those with existing deficiencies. However, more research is needed to establish a direct causal relationship between Vitamin D3 supplementation and cardiovascular disease prevention.
Vitamin K2, on the other hand, plays a crucial role in calcium homeostasis and arterial health. It helps prevent calcium from depositing in the arteries, which can lead to atherosclerosis, a major risk factor for heart disease. Regular intake of Vitamin K2, especially when paired with Vitamin D3, may support better cardiovascular health by promoting proper calcium distribution in the body. While initial findings are promising, it is essential to consult with healthcare professionals for tailored advice, as they can provide recommendations based on individual health needs and the latest research. In summary, while there may be potential for these vitamins to support cardiovascular health, definitive conclusions are yet to be drawn.
Based on user reviews, many individuals report experiencing positive effects on their cardiovascular health within a relatively short timeframe. Some users observed significant improvements in their overall well-being and cardiovascular metrics after just a few days of taking the supplement. For instance, one reviewer noted a drastic reduction in bleeding frequency and joint pain by the second day of use, while another emphasized noticeable enhancements in cardiovascular health and overall strength after a month (Read Review).
Additionally, other users highlighted that consistent use of the supplement led to long-term health benefits, particularly in managing calcium's role in cardiovascular health. Many users shared that incorporating vitamins D and K along with iodine contributed significantly to their cardiovascular improvement, indicating the potential for both short and longer-term results (Read Review; Read Review). Ultimately, while individual results may vary depending on personal health factors and consistency of use, it seems users generally note improvements within days to a month of use.
The current scientific research on vitamin D, particularly vitamin D3, presents a complex picture regarding its potential role in cardiovascular health. Several studies indicate that vitamin D may have a beneficial impact on certain cardiovascular disease (CVD) risk factors, particularly in populations with specific health concerns such as chronic kidney disease and ischemic heart disease. For example, a recent randomized clinical trial revealed that vitamin D supplementation improved lipid profiles in ischemic heart disease patients, increasing levels of high-density lipoprotein cholesterol while reducing triglycerides [1]. Moreover, observational studies suggested potential associations between vitamin D levels and various cardiovascular health indicators, although these findings do not establish direct causation [6].
However, it's important to note that many studies do not conclusively support the use of vitamin D3 as a standalone treatment for cardiovascular disease. For instance, while vitamin D treatments appeared to mitigate some adverse effects related to hypertrophy in heart cells, the effects depended heavily on the presence of particular proteins essential for cellular protection [2]. Additionally, in patients with multiple sclerosis, sufficient vitamin D levels correlated with lower cardiovascular event risks, but supplementation did not significantly reduce this risk compared to those with adequate baseline levels [4]. Overall, while there are promising indications regarding the benefits of vitamin D3 on heart health, further targeted research is warranted to clarify its specific impacts and therapeutic potential.
Based on user reviews, many individuals have reported significant improvements in their cardiovascular health associated with the combination of vitamins D and K, particularly when taken with iodine. For instance, one user noted that by the second day of use, they experienced a notable reduction in bleeding frequency and less reliance on painkillers due to diminished joint pain, emphasizing the rapid efficacy of the supplement (Read Review). Furthermore, other reviewers highlighted that the synergistic effects of these vitamins not only facilitated better calcium metabolism, preventing arterial calcium build-up, but also enhanced overall well-being and stamina over a period of weeks (Read Review; Read Review).
A variety of users noted that they felt an increase in energy levels and improved cardiovascular metrics after incorporating these vitamins into their routine. One reviewer specifically praised the formula for its convenience and effectiveness, asserting that it had been crucial in improving not only their own health but that of their family and clients, despite recommending caution for those with specific medical conditions (Read Review; Read Review). Overall, while results can vary based on individual health factors, many users have expressed a high degree of satisfaction with the benefits this supplement offers to their cardiovascular and overall health.
Users report a multitude of benefits when combining this supplement with others for managing cardiovascular disease. Many individuals emphasize the synergistic effects of vitamins D and K, particularly when taken with iodine, for enhancing cardiovascular health and overall well-being. For instance, one reviewer mentioned experiencing substantial improvements in symptoms during an illness when they combined it with vitamin C and zinc, highlighting the importance of a well-rounded supplement regimen in supporting their cardiovascular system during challenging times (Read Review). Another user praised the effectiveness of the D3-K2 combination in ensuring that calcium is directed to bone rather than soft tissues, underscoring its protective role against cardiovascular issues (Read Review).
Moreover, several reviewers pointed out that incorporating additional supplements like magnesium and vitamin C could enhance the benefits of vitamin D and K for cardiovascular health. One noted the importance of taking magnesium alongside these vitamins, as they work synergistically to address cardiovascular disease effectively (Read Review). Additionally, users have emphasized the convenience of a combination supplement that packs multiple essential nutrients into one capsule, making it easier to maintain consistency in their health regimen while maximizing cardiovascular protection (Read Review). Overall, the feedback suggests that combining these nutrients can significantly improve cardiovascular outcomes and overall health.
Users report a variety of doses and combinations of Vitamin D3 and K2 that they have found effective for treating cardiovascular disease. A notable mention is the combination of Vitamin D3 (with some users highlighting doses as high as 5000 IU) and K2, which users believe work synergistically to enhance calcium absorption and distribution in the body. Several reviewers also point out that Vitamin K2 is crucial in directing calcium towards bones and away from soft tissue, thereby supporting cardiovascular health (review-id: Read Review).
Moreover, users appreciate formulations that combine both vitamins along with iodine, which they claim benefits overall well-being and cardiovascular functions. For instance, one user mentions a product that includes 125 mcg of Vitamin D3 and 2100 mcg of Vitamin K, suggesting a well-formed ratio that supports not just cardiovascular health but other vital bodily functions (review-id: Read Review). Overall, while individual needs can differ, many users recommend consulting healthcare professionals for personalized dosage advice based on health conditions and lifestyles.
7.5
Improved cardiovascular health
210 people found this helpful
In particular, with severe osteoporosis and blood clotting issues, I noticed significant improvements in my overall state in a short time. By the second day, bleeding frequency reduced drastically, and joint pain diminished enough for less reliance on painkillers. After a month, my condition was vastly better. The capsules are small, with an excellent composition. Vitamin K enhances vitamin D absorption, which is vital for my health, given the Ural climate's lack of sun.
7.5
Calcium absorption support
1 people found this helpful
Due to age, it’s necessary to supplement calcium with vitamins D and K to direct calcium to the bones and prevent issues related to cardiovascular disease. This product conveniently delivers all necessary nutrients, including iodine, for overall health.
9
Effective composition
I started this supplement due to calcium affecting my cardiovascular system. It effectively directs calcium to my bones and protects my blood vessels. I highly recommend it, especially in areas with limited sunlight.
7.5
Well-rounded support
1 people found this helpful
I found this to be effective for my bone, immune, and cardiovascular health. The combination of various forms of vitamin K2 makes this a well-rounded supplement. I advise consulting a healthcare professional beforehand since not everyone may require high doses.
9
Universal health benefits
3 people found this helpful
This supplement is essential for everyone, given my experience as a trainer and nutritionist. My entire family has benefited, as well as my clients, with notable improvements in well-being and cardiovascular health. However, I advise against its use for those with thyroid or heart conditions.
7.5
Strengthens cardiovascular system
2 people found this helpful
The three-in-one product format is convenient, combining vitamins D and K, along with iodine. It effectively supports bone and gland health, helping prevent thyroid disease due to iodine deficiency. The quality is excellent, and it contributes remarkably to my cardiovascular strength.
9
Effective vitamin combo
9 people found this helpful
Checked, it works. The combination of vitamins D and K is excellent. I feel superb after taking it with omega and vitamin C. During a recent illness, I found taking a loading dose along with vitamin C and zinc crucial; I experienced minimal symptoms. This product is just what I needed, and I appreciate its efficacy, so I encourage others to try it for their cardiovascular health.
7.5
Bone health improvement
11 people found this helpful
I take Vitamin K2 with Vitamin D3 to ensure calcium is absorbed in my bones rather than in soft tissues, which protects against cardiovascular disease. Despite doctors often neglecting K2, its benefits, such as reducing fracture risk, are significant.
9
Supports immune health
1 people found this helpful
Vitamin D-3 is critical for immune support. If you're not in a sunny area, supplementation is often necessary, and I take 5000 IU. Remember to take Magnesium and Vitamin K2 alongside, as they work together for cardiovascular disease treatment.
9
Cognitive health support
This formula provides essential nutrients: 125 mcg Vitamin D3, 2100 mcg Vitamin K, and 1000 mcg iodine, supporting cardiovascular disease and cognitive health. Maintaining healthy vitamin levels is vital for bone density and overall well-being.
7
Vitamin D3's cardiovascular association analyzed
[Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES].
We explored how serum levels of vitamin D3, specifically 25(OH)D, might influence various indicators related to cardiovascular health. Using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2015 to 2018, we analyzed results from 4,727 adults aged 20 and above.
Our investigation focused on several key factors such as body mass index, high-density lipoprotein cholesterol, systolic blood pressure, and cholesterol levels. The results showed that even a slight increase in vitamin D3 levels was associated with positive changes across these cardiovascular risk factors. For instance, we found that a 1 nmol/L increase in serum 25(OH)D led to small but significant improvements in several indicators.
Notably, the effects varied by gender and age, with women showing greater sensitivity to vitamin D3 levels compared to men, while older adults were less responsive. However, our findings highlighted a complex relationship, revealing nonlinear patterns that suggest additional research is necessary to fully understand these dynamics. While the results display promising associations, they do not confirm that vitamin D3 treatment can directly improve cardiovascular disease outcomes.
7
Vitamin D3 aids heart health
Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts.
We explored the effects of vitamin D3 (VitD) on heart cells, focusing on its ability to counteract changes induced by angiotensin II (Ang II), a compound that can contribute to heart disease. The study involved exposing H9c2 cardiomyoblasts—heart muscle cells—to Ang II alone, and then to both Ang II and VitD to see how VitD might help.
Our findings revealed that while VitD effectively reduced the size of the cells and helped lower markers of hypertrophy (a condition where heart cells enlarge often due to strain), it did not significantly improve cell survival in the absence of a protein called sirtuin-1 (SIRT1). When SIRT1 was inhibited, VitD was unable to protect the cells as it normally would. This suggests that SIRT1 is crucial for the pro-survival benefits of vitamin D.
Importantly, while VitD showed promise in tackling hypertrophy, its protective effects rely heavily on SIRT1 being present. This could lead to new ideas for therapies in heart disease, where activating SIRT1 might enhance the benefits of vitamin D to improve heart health.
3
Vitamin D3's limited heart health effects
Vitamin D and cardiovascular outcomes in multiple sclerosis.
We explored the connection between vitamin D levels and cardiovascular health in people with multiple sclerosis (pwMS). Specifically, our study examined the effects of vitamin D3 treatment on heart-related outcomes among patients with differing levels of vitamin D. Using data from 70 healthcare organizations over a period of five years, we focused on individuals who had either deficient or adequate vitamin D levels.
Our findings revealed that pwMS with deficient or inadequate vitamin D levels experienced an increased risk of major adverse cardiovascular events (MACE), including heart attacks and strokes. Importantly, while some pwMS received cholecalciferol (a form of vitamin D3) supplementation, this did not significantly reduce their risk of heart problems compared to those with adequate vitamin D levels who were not taking supplements.
Overall, our inquiry shows that simply having adequate vitamin D is crucial, but supplementation with vitamin D3 alone may not confer the expected cardiovascular protective benefits for pwMS. This suggests that more comprehensive strategies may be needed to address heart health in these patients.
References
Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. 10.1186/s12882-025-04041-2
Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
Qi RQ, Chen YF, Cheng J, Song JW, Chen YH, et al. Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. Mol Med. 2024;30:223. 10.1186/s10020-024-00997-3
France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, et al. Vitamin D and cardiovascular outcomes in multiple sclerosis. Mult Scler Relat Disord. 2024;92:106155. 10.1016/j.msard.2024.106155
Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
Pan YX, Fu YC, Chen H, Zhao MY. [Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:1388. 10.3760/cma.j.cn112150-20240519-00403